Vitamin K2 (MK-7)

Tier 2 — promising · Bone · Vascular calcification

Directs calcium into bones and away from arteries, reducing calcification risk. The Rotterdam Study (4,807 people) linked higher dietary K2 intake to 57% fewer heart disease deaths — an observational association, not a supplement trial. Pairs synergistically with vitamin D3 for bone health. WARNING: directly antagonises warfarin — never take without medical supervision.

Dose: 90–200 mcg/day MK-7 with fat, paired with Vitamin D3; AVOID if on warfarin without medical supervision