Do you need vitamin K2 with vitamin D?

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Bottom line

You do not need vitamin K2 just because you take vitamin D. The randomized AVADEC trial gave vitamin K2 and vitamin D to people with aortic valve calcification and did not show slower valve disease. Vitamin D still has a dietary allowance of its own. K2 has a separate, thinner evidence file. Buy the combination only if you have a reason for both, not because a label says they belong together.

The combination bottle is one of the most common add-ons sold next to vitamin D3. Vitamin K2 (MK-7) is a real compound with its own research. It is not a required partner.

The valve trial

The AVADEC trial randomized people with aortic valve calcification to vitamin K2 plus vitamin D or to placebo (PMID 35465686, Circulation). The combination did not slow the valve disease the trial was built to measure. That is a direct answer to the claim that the pair protects arteries or valves in this setting. It is not a finding that vitamin D itself is useless for its actual jobs, which are nutritional.

When K is a drug interaction

Vitamin K interferes with warfarin. A K2 softgel is not a casual add for anyone on that drug. For everyone else, a vitamin D product in the 600 to 2,000 IU range does not become incomplete because K2 is missing. See vitamin D in a Canadian winter for the allowance and the upper limit.

Sources

  1. Vitamin K2 and D in patients with aortic valve calcification: a randomized double-blinded clinical trial. Circulation. 2022. PMID: 35465686.
  2. NIH Office of Dietary Supplements. Vitamin D fact sheet for health professionals. NIH ODS.