About SupplementScore

Honest, independent supplement evidence — free for everyone.

SupplementScore is a public, free reference that grades dietary supplements against published clinical trials. Every score traces back to peer-reviewed research. No sponsorships, no affiliates, no ads.

733+
Supplements scored
61
Research sources
27,000+
Studies reviewed
$0
Industry funding

Evidence tiers

Every supplement is classified by the strength and consistency of its human clinical data.

01
Proven Effective
Backed by multiple large clinical trials, systematic reviews, and meta-analyses. Consistent, replicated results across independent research groups. Considered safe and effective by the WHO, NIH, and EFSA.
RCTs & meta-analyses
02
Promising
Supported by clinical trials but evidence is limited to specific populations, conditions, or dosages. Shows real potential but may not benefit everyone equally — awaiting larger confirmatory studies.
Smaller RCTs
03
Unproven
Limited or conflicting human data. Marketing claims often exceed the research. Many popular supplements fall here — strong animal data does not equal clinical evidence. Approach with skepticism.
Animal / in-vitro / pilot
04
Risky
Documented safety risks including organ damage, severe drug interactions, or death. Regulatory warnings issued by the FDA, WHO, or equivalents. Includes banned substances and compounds with no safe dose.
Safety concerns

How scoring works

Four steps from the literature to a score you can trust.

Step 01
Active
Literature search

Priority for systematic reviews, meta-analyses, and Cochrane reviews. Individual RCTs used when no meta-analysis exists. Industry-funded studies flagged and weighted lower.

Step 02
Active
Quality grading

Each study graded for blinding, allocation concealment, sample size, and statistical power. Effect sizes and confidence intervals recorded for every key outcome.

Step 03
Active
Score calculation

Rated across 6 dimensions: Efficacy, Safety, Research depth, Onset, Cost-effectiveness, and Drug interactions. Efficacy weighted highest. Only human clinical data.

Step 04
Advisory board planned
Ongoing review

Scores evolve as new evidence is published. AI-assisted synthesis cross-referenced against Cochrane, PubMed, NIH, and WHO. Content reviewed and updated regularly.

Roadmap

Four stages toward hyper-personalized supplement recommendations.

Stage 01 Active
Comprehensive supplement database
733+ supplements evaluated across 6 clinical dimensions, every rating derived from systematic reviews, meta-analyses, and human clinical trials across 61 peer-reviewed sources. Continuously updated.
Stage 02 In progress
Personalized recommendations
Profile-based engine that generates a custom supplement plan from your age, sex, goals, conditions, and medications — what to take, what to avoid, dosing, timing, and interactions.
Stage 03 Coming soon
Blood work & lab integration
Upload blood panels or urine tests to identify specific deficiencies. Results are analysed against optimal ranges to recommend targeted supplements for what your body actually needs.
Stage 04 Planned
DNA-based hyper-personalization
Incorporate MTHFR, VDR, CYP, and APOE variants to refine recommendations based on how you absorb, metabolise, and respond to specific nutrients — the most precise level of personalization.
Why we exist.

The right supplement can genuinely change someone's quality of life. Better sleep. Less joint pain. More energy. Reduced anxiety. For people managing health conditions, nutrient deficiencies, or simply trying to age well, the difference between the right supplement and the wrong one can be profound. But finding honest information is nearly impossible — the supplement industry generates over $50 billion a year, and most of what you read online is written by someone trying to sell you something.

We built SupplementScore to fix that. Our goal is to use the latest advances in AI and machine learning to curate precise, personalized supplement regimens based on each individual's blood work, lab results, and eventually DNA.

We don't sell supplements. We don't accept sponsorships. We don't run affiliate links. Our goal is to keep SupplementScore free and transparent for everyone to use.

$50B+
spent annually on supplements in the U.S. alone — most without sufficient evidence to justify the claim on the label.
  • Radical transparency
    Every score is fully traceable to its source studies. No black boxes, ever.
  • Independence first
    Zero industry funding. Zero affiliate deals with brands we score. Full stop.
  • Living knowledge
    Scores evolve as evidence evolves. Science is never settled, and neither are we.
Important disclaimer
  • Educational reference, not a medical device — SupplementScore is not reviewed by the FDA, Health Canada, or any regulatory body.
  • Scores reflect group-level clinical data; individual responses vary by genetics, diet, health status, medications, and pre-existing conditions.
  • Supplement quality varies dramatically between brands. We do not test, certify, or endorse specific products.
  • Nothing here is intended to diagnose, treat, cure, or prevent any disease. Always consult a qualified healthcare provider before starting, stopping, or changing supplements — especially if you are pregnant, nursing, or on medications.
  • In a medical emergency, contact your local emergency services immediately.
Contribute

Help us make the data even better.

SupplementScore is a community effort. Clinicians, researchers, and developers make our data better every day — corrections, new evidence, or partnership all welcome.

Clinicians
Researchers
Developers
Corrections
Funding
Social media
We'll respond within 2 business days. No newsletters — just real conversations.
Latest data revisions
Apr 16, 2026Added 50 new supplements (733 total) spanning mitochondrial, vitamin E isomers, HMO prebiotics, omega-3 plant oils, and chelated mineral forms. Added 12 new sources across academic centres, systematic reviews, and specialty journals (55 total).
Apr 15, 2026Added 25 new supplements (653 total). Added 4 new sources: European Journal of Nutrition, Frontiers in Nutrition, International Osteoporosis Foundation, American Diabetes Association (43 total).
Apr 14, 2026Added 5 new sources: ClinicalTrials.gov, AHRQ, Annals of Internal Medicine, American Botanical Council, WADA (39 total).
Apr 11, 2026Added 50 new supplements (628 total). Added cycling/duration guidance.
Apr 10, 2026Updated Omega-3 description — corrected VITAL trial data attribution.
Apr 10, 2026Vitamin K2 drug interaction score upgraded to “significant” (warfarin).
Apr 9, 2026Added 3 new sources: BMJ, JAMA Network, FDA Database.
Apr 8, 2026Creatine for Brain Health article published.
Apr 5, 2026Sleep Stack protocol article published.
Apr 1, 2026Improved recommendation engine for seniors — added Calcium, Phosphatidylserine.