Theacrine (TeaCrine)

Tier 2 — promising · Energy · Focus · Tolerance-free

Provides clean energy similar to caffeine but without the tolerance buildup. 2024 trials found comparable energy and focus benefits with no tolerance even after 8 weeks of daily use. Unlike caffeine, it doesn't raise heart rate or blood pressure. Can be combined with caffeine for a stronger effect without jitters. Well tolerated in studies.

Dose: 100–200 mg/day; can combine with caffeine for synergistic effect without jitters