D-Ribose

Tier 3 — weak evidence · Energy · Heart failure · Fibromyalgia

A naturally occurring sugar that your body uses to rebuild ATP, the primary energy molecule in every cell. Small trials in heart failure and fibromyalgia patients show improved energy and exercise tolerance, but study quality is generally low. Does not appear to benefit healthy people who are not energy-depleted. May cause blood sugar spikes in diabetics. Generally safe at standard doses for most people.

Dose: 5 g × 3 daily for heart failure or fibromyalgia; no benefit demonstrated in healthy adults