Akkermansia muciniphila

Tier 3 — weak evidence · Gut barrier · Metabolic · Obesity

A next-generation probiotic that lives in the mucus layer of your gut and strengthens the intestinal barrier. Low levels of Akkermansia are consistently linked to obesity, diabetes, and inflammatory bowel disease. The landmark Depommier et al. 2019 Nature Medicine pilot (n=32 overweight/insulin-resistant adults, 3 months, Louvain group) found pasteurised Akkermansia improved insulin sensitivity, HOMA-IR, total cholesterol, and body weight vs placebo. Still expensive and available from very few manufacturers. Research is promising but very early stage.

Dose: 10 billion CFU/day pasteurised Akkermansia muciniphila; very early-stage research; expensive