Butyrate (calcium/magnesium)

Tier 2 — promising · Gut barrier · IBD · Microbiome

A short-chain fatty acid produced by gut bacteria fermenting fibre. Supplemental butyrate (calcium or magnesium salt) supports gut barrier integrity and reduces intestinal inflammation. Small trials show benefit in ulcerative colitis and IBS. Enteric-coated capsules preferred for colonic delivery. Has an unpleasant odour — keep container tightly sealed.

Dose: 300–1,200 mg/day calcium or magnesium butyrate; enteric-coated for colonic delivery