Tributyrin / Butyrate

Tier 2 — promising · Gut barrier · Microbiome · Inflammation

Butyrate is the main fuel source for the cells lining your colon and is critical for maintaining gut barrier health. The tributyrin form survives stomach acid better than sodium butyrate and releases butyrate directly in the colon. 2024 trials show improved gut lining integrity. Generally safe but can cause mild digestive changes initially.

Dose: 300–600 mg/day tributyrin; or 2–4 g/day sodium butyrate