Activated B complex (methylated)

Tier 3 — weak evidence · Energy · Mood · Methylation

A B-complex formula using pre-methylated forms (methylfolate, methylcobalamin, P5P) that bypass the MTHFR enzyme. Clinical benefit is clearest for people with confirmed MTHFR mutations and elevated homocysteine. Most healthy adults absorb standard B vitamins effectively and gain little advantage from the more expensive methylated versions. Avoid late-day dosing.

Dose: 1 capsule/day providing methylated B12, folate, and B6 (P5P); most useful with confirmed MTHFR variants