Pregnenolone

Tier 3 — weak evidence · Hormonal · Cognition · Mood

A precursor hormone your body uses to make cortisol, DHEA, progesterone, and testosterone. No high-quality trials support the cognitive or mood benefits sometimes claimed. Can disrupt hormonal balance and cause unwanted side effects. Requires regular hormone panel monitoring. Not recommended for healthy adults without medical guidance.

Dose: 10–30 mg/day if clinically indicated; not recommended without hormone panel monitoring