Diindolylmethane (DIM)

Tier 2 — promising · Hormonal · Oestrogen balance · Detox

The active metabolite of indole-3-carbinol (I3C) produced during cruciferous vegetable digestion. DIM shifts oestrogen metabolism toward less active 2-hydroxy forms and away from more stimulatory 16-alpha-hydroxy metabolites. Human RCTs show benefit for PMS severity, hormone ratio improvement, and fibrocystic breast disease. Emerging prostate health data. Unlike I3C, DIM is more bioavailable and does not form undesirable condensation products at higher doses.

Dose: 100–300 mg/day with a fat-containing meal