Mitoquinol (MitoQ)

Tier 3 — weak evidence · Mitochondrial · CoQ10 derivative · Longevity

Triphenylphosphonium-conjugated ubiquinol that accumulates ~1,000-fold in mitochondria. Strong preclinical antioxidant data; human RCTs in cardiovascular endothelial function (Rossman 2018) and NAFLD show modest benefit. Cost is high; standard ubiquinol is cheaper and supported by larger RCTs. Reserve MitoQ for specific endothelial-dysfunction or research contexts.

Dose: 5-20 mg/day