CoQ10 (Ubiquinol)

Tier 2 — promising · Heart failure · Statin users

Supports heart health and energy production in every cell. The Q-SYMBIO trial found 300 mg/day reduced cardiovascular deaths by ~43% in heart failure patients, confirmed by a 2023 meta-analysis. Statins deplete CoQ10 levels in the body, making supplementation especially important if you take statins. Ubiquinol absorbs significantly better than ubiquinone, particularly for adults over 40.

Dose: 200–400 mg/day ubiquinol with a fatty meal; heart failure trials use 300 mg/day