Dihydroberberine (DHB)

Tier 3 — weak evidence · Blood sugar · Bioavailability · Metabolic

A reduced form of berberine absorbing 5 times better than standard berberine, with similar glucose-lowering at a lower dose and fewer GI side effects. A 2024 trial found 100 mg DHB equivalent to 500 mg standard berberine. Still emerging with limited long-term data. Drug interactions mirror berberine.

Dose: 100–300 mg/day DHB; equivalent to 500–1,500 mg standard berberine at lower dose with less GI upset