Calcium alpha-ketoglutarate (Ca-AKG)

Tier 2 — promising · Longevity · TCA cycle · Epigenetics · Biological age · Muscle

A key intermediate in the Krebs cycle and co-factor for over 60 enzymes including alpha-ketoglutarate-dependent dioxygenases that regulate DNA and histone methylation (epigenetic aging clocks). Serum AKG declines 10-fold between age 30 and 80. Shahmirzadi et al. 2020 (Cell Reports, mouse lifespan and healthspan extension) and a subsequent Rejuvant human cohort (Asprinio 2021 preprint, N=42) reported biological-age reductions on the GrimAge epigenetic clock — the human data was a preprint cohort, not a peer-reviewed RCT. Also involved in collagen synthesis, ammonia detoxification, and…

Dose: 1,000–2,000 mg/day Ca-AKG; typically taken in the morning on an empty stomach or with a light meal