Yohimbe bark (Pausinystalia yohimbe)

Tier 4 — risky / avoid · Cardiac arrhythmia · Hypertensive crisis

Yohimbine, the active compound in yohimbe bark, is a potent stimulant with a narrow safety window. Multiple reports of dangerous blood pressure spikes, heart attacks, and seizures are linked to bark supplements. FDA warns yohimbine content varies by up to 10-fold between products, making dosing unpredictable and dangerous. Prescription yohimbine HCl is the only regulated option.

Dose: AVOID supplement-form yohimbe bark entirely — unpredictable dosing causes cardiac emergencies; prescription yohimbine HCl only under medical supervision