Wobenzym (systemic enzymes)

Tier 2 — promising · Inflammation · Recovery · OA

A combination of digestive enzymes and plant compounds used widely in European sports medicine. A 2024 review of 11 trials found it works as well as ibuprofen-type painkillers for knee arthritis with significantly fewer stomach side effects. Take on an empty stomach 30 minutes before meals for anti-inflammatory effects. Well tolerated overall.

Dose: 2–3 tablets, three times daily (6–9 tablets/day total) on an empty stomach (≥30 min before meals or ≥2 hours after). Sustained use 4–8 weeks for inflammation outcomes.