Vitamin E (mixed tocopherols)

Tier 3 — weak evidence · Antioxidant · Skin · NAFLD

The NIH-funded PIVENS trial found 800 IU/day significantly improved liver histology in non-alcoholic fatty liver disease (NASH). Use mixed tocopherols (not just alpha-tocopherol alone) for general antioxidant purposes. Cochrane meta-analysis found doses above 400 IU/day associated with modestly increased all-cause mortality — high-dose use requires medical supervision.

Dose: 200–400 IU/day mixed tocopherols for general use; 800 IU/day for NASH only under medical supervision