Tocotrienols (annatto-derived)

Tier 3 — weak evidence · Cardiovascular · Neuroprotection · Vitamin E

The delta and gamma tocotrienol fractions from annatto seeds are the most potent natural tocotrienols, free from the alpha-tocopherol that competes for absorption. Emerging trials show they reduce LDL cholesterol, suppress inflammatory cytokines, and may protect against metabolic syndrome. Qureshi 2001 hypercholesterolaemia trials (early LDL-lowering data) and Chin 2011 in osteopenic women are the most-cited anchors; annatto-tocotrienol NAFLD trials (Pervez 2020 and others) are promising but small.

Dose: 100–200 mg/day delta/gamma tocotrienols from annatto; take with a fatty meal; avoid with alpha-tocopherol