Skullcap (Scutellaria lateriflora)

Tier 3 — weak evidence · Anxiety · Sleep · Neuroprotection

An American herb traditionally used for anxiety and nervous tension. Very few human trials exist, and only one small study found modest anxiety reduction. Adulteration with germander, a toxic herb that causes liver damage, has been reported in some commercial products. Buy only from verified sources with third-party testing to avoid this risk.

Dose: 350–500 mg/day; buy only from verified sources — adulteration risk with hepatotoxic herbs