Magnolia bark (honokiol + magnolol)

Tier 2 — promising · Anxiety · Sleep · Cortisol

Contains two potent bioactive compounds, honokiol and magnolol, that activate GABA receptors similarly to benzodiazepines but without addiction potential. Clinical trials show significant anxiety reduction and improved sleep quality. Also modestly lowers cortisol. Commonly combined with ashwagandha or L-theanine in sleep formulas. Generally well tolerated at recommended doses.

Dose: 200–400 mg/day bark extract standardised to 2% honokiol + magnolol; take in evening for sleep