Serrapeptase

Tier 3 — weak evidence · Anti-inflammatory · Sinus · Swelling

An enzyme with strong anti-inflammatory activity in lab studies, but Cochrane found insufficient evidence for any real-world use. European food safety authorities rejected all submitted health claims. Sometimes marketed for sinus pain and post-surgical swelling. Must use enteric-coated capsules because stomach acid destroys the enzyme otherwise.

Dose: 10–60 mg/day enteric-coated; evidence base too weak to recommend