Policosanol

Tier 3 — weak evidence · Cholesterol · Cardiovascular

Derived from sugar cane wax and marketed for cholesterol reduction. Cuban studies claimed dramatic cholesterol reductions, but every independent study conducted outside Cuba has consistently shown no significant effect. This is a notable example of research results that could not be replicated by other laboratories. Not recommended for cholesterol management.

Dose: 10–20 mg/day; independent studies found no benefit — Cuban results not replicated