Pantethine

Tier 2 — promising · Cholesterol · Triglycerides · CoA precursor

The active form of vitamin B5 that your body uses to make coenzyme A. Multiple trials show 600 to 900 mg per day significantly lowers total cholesterol by about 11 percent and triglycerides by about 30 percent. Works through a different mechanism than statins, so it can be used alongside them. Generally well tolerated with mild digestive side effects in some people. Takes 4 to 8 months for full lipid-lowering effect.

Dose: 300 mg × 2–3 daily with meals; allow 4–8 months for full cholesterol-lowering effect