Palmitoylethanolamide (PEA)

Tier 2 — promising · Neuropathic pain · Inflammation

A natural pain-relieving compound your body already makes in small amounts. A 2024 review of 16 trials found PEA significantly reduces neuropathic and arthritis pain. Excellent safety profile — no known drug interactions reported in any trial. Must use ultramicronised (um-PEA) or co-micronised forms; standard PEA absorbs poorly and may not work. Allow 4–8 weeks for full effect.

Dose: 300–600 mg/day ultramicronised or co-micronised form (um-PEA or co-PEA); standard form poorly absorbed