Agmatine sulfate

Tier 3 — weak evidence · Neuropathic pain · Mood · Athletic

Shows promise for nerve pain and mood improvement, but evidence is very early-stage. A handful of small trials show pain reduction for nerve pain and modest mood benefits. Fewer than 5 human trials exist in total, making this largely experimental. Long-term safety beyond 5 months is unclear. Not recommended as a first-line supplement.

Dose: 1–2.67 g/day for neuropathic pain; safety beyond 5 months unclear