Oat avenanthramides

Tier 3 — weak evidence · Cardiovascular · Anti-inflammatory · Skin

Polyphenolic amides unique to oats (primarily avenanthramides A, B, and C), distinct from the beta-glucan fibre fraction. Unlike oat beta-glucan which acts in the gut lumen, avenanthramides are absorbed systemically and exert anti-inflammatory, vasodilatory (via nitric oxide), and antioxidant effects. Human trials show reductions in LDL oxidation, improved endothelial function, and reduced platelet aggregation. Complementary to — not duplicative of — oat fibre benefits.

Dose: 50–250 mg avenanthramide-rich oat extract daily