Nattokinase

Tier 3 — weak evidence · Cardiovascular · Fibrinolysis · Blood pressure

A natural enzyme from fermented soybeans that may support cardiovascular health. A 2024 review of 15 trials found nattokinase significantly lowers blood pressure by about 4.5 mmHg and reduces blood-clotting protein levels. Do not take with blood thinners like warfarin or aspirin, as the combined effect could cause dangerous bleeding.

Dose: 2,000–4,000 FU/day (100–200 mg); AVOID with warfarin, aspirin, or other blood thinners