NAD+ IV infusion therapy

Tier 3 — weak evidence · Anti-aging · Energy · Clinic-based

IV infusion of NAD+ directly into the bloodstream bypasses the need for oral precursors. Longevity clinics charge 500–1,500 USD per session. A 2024 pilot study found IV NAD+ acutely increased blood NAD+ by 400% but levels returned to baseline within 24 hours. No evidence it provides lasting benefits over oral NR or NMN supplementation. Side effects include chest tightness, nausea, and flushing during infusion.

Dose: 250–500 mg IV NAD+ infused over 2–4 hours in a clinical setting; 500–1,500 USD per session