C60 fullerene (carbon 60)

Tier 3 — weak evidence · Anti-aging · Antioxidant · Experimental

A spherical carbon molecule that gained attention after a 2012 rat study showed dramatic lifespan extension. However, that study had major methodological flaws and has not been replicated. No human clinical trials exist. Dissolved in olive oil for oral use, the particle safety profile is completely unknown at chronic doses. Quality control is extremely poor — many products contain impurities or inadequate amounts.

Dose: No established safe human dose; the rat study used C60 in olive oil but is methodologically flawed and unreplicated