Mangosteen (Garcinia mangostana)

Tier 3 — weak evidence · Antioxidant · Inflammation · Xanthones

Contains unique xanthones including alpha-mangostin with anti-inflammatory activity in lab studies. Marketed as a superfruit juice in the 2000s with exaggerated claims. Very few human trials exist; one showed modest improvements in inflammation. The fruit is safe as food. Supplement evidence is almost entirely preclinical.

Dose: 500–1,000 mg/day mangosteen extract; most evidence is preclinical; fruit is safe as food