Luteolin

Tier 3 — weak evidence · Cognition · Neuroprotection · Inflammation

A flavone found in parsley, celery, and chamomile with potent anti-neuroinflammatory properties. Luteolin inhibits microglial activation, reduces pro-inflammatory cytokines (TNF-α, IL-6), and stabilises mast cells — making it particularly relevant for brain fog, mast cell activation syndrome, and neurological conditions. Preliminary human trials show benefit in autism spectrum disorder-related irritability and cognitive performance. Crosses the blood-brain barrier modestly.

Dose: 100–300 mg/day with a fat-containing meal