Citicoline (CDP-Choline)

Tier 2 — promising · Cognition · Stroke recovery · Memory

Supports brain function by providing choline in a form that readily crosses the blood-brain barrier. A 2024 review of 22 trials found it significantly improves thinking ability in mild cognitive decline. Better tolerated than Alpha-GPC with no stroke risk concerns raised. Also used in European hospitals as part of stroke recovery protocols. Most people don't get enough choline from diet alone.

Dose: 250–500 mg/day for cognition; 500–2,000 mg/day in stroke recovery protocols