Lactobacillus plantarum 299v

Tier 2 — promising · Probiotic strain · IBS · Iron absorption

LP299v (Lactiplantibacillus plantarum 299v) has clinical evidence across at least three distinct domains. For IBS, Goodoory 2023 Gastroenterology meta-analysis (82 RCTs, PMID 37541528) found LP299v shows low-certainty benefit for global IBS symptoms — among the more specific strains positively identified. For mood/cognition: Rudzki 2018 RCT (79 MDD patients on SSRIs, PMID 30388595) found LP299v supplementation significantly improved cognitive performance and reduced kynurenine levels vs placebo; a 2024 metabolomics follow-up (PMID 39271063) extended these findings to mitochondrial and…

Dose: 10–20 billion CFU/day. For iron absorption enhancement, take simultaneously with iron and vitamin C. For IBS and mood, take daily for at least 4–8 weeks.