Inositol myo-form (PCOS/metabolic)

Tier 2 — promising · PCOS · Insulin sensitivity · Ovulation

Myo-inositol is one of the most used supplements for polycystic ovary syndrome. A 2024 systematic review and meta-analysis by Fitz and colleagues (30 trials, n=2,230, PMID 38163998), prepared to inform the 2023 International Evidence-Based PCOS Guidelines, found evidence suggests benefits for some metabolic measures and potential benefit for ovulation, but found the overall evidence 'limited and inconclusive' across most outcomes. The 40:1 myo:D-chiro-inositol combination mirrors the body's natural tissue ratio. Adverse effects are mild and GI-limited. Key caveat: clinical guidelines do…

Dose: 2,000–4,000 mg/day myo-inositol; 40:1 myo:D-chiro-inositol combination preferred for PCOS; split into 2 doses.