D-Chiro Inositol

Tier 2 — promising · PCOS · Insulin sensitivity · Ovulation · 40:1 ratio · Hormone balance

A secondary messenger that mediates insulin signalling in muscle and ovarian tissue. Women with PCOS are deficient in D-chiro inositol due to an enzyme defect impairing its synthesis from myo-inositol. The optimal protocol is myo-inositol:D-chiro inositol in a 40:1 ratio, mirroring the physiological tissue ratio. Multiple RCTs confirm the 40:1 combination restores ovulation, lowers androgens, improves AMH levels, and reduces insulin resistance better than either alone. Critically: high-dose D-chiro inositol alone (600 mg+ without myo-inositol) can paradoxically worsen oocyte quality and…

Dose: Take as the 40:1 myo:DCI ratio (most studied: 1,100 mg myo-inositol + 27.6 mg D-chiro twice daily); do not take D-chiro alone at high doses