Inositol hexanicotinate

Tier 2 — promising · Cardiovascular · Lipids · Niacin

A slow-release niacin form where six niacin molecules are esterified to inositol, marketed as flush-free niacin. Slower hydrolysis yields lower peak plasma niacin than immediate-release forms — explaining both reduced flushing and weaker lipid effects observed in controlled trials. Modest triglyceride reductions and small HDL increases have been documented. Appropriate for individuals genuinely intolerant of niacin flushing who still want some lipid support, but should not substitute for pharmacological niacin when strong effects are needed.

Dose: 1,000–1,500 mg/day in divided doses with meals