Guggul (Commiphora mukul)

Tier 3 — weak evidence · Cholesterol · Thyroid · Inflammation

An Ayurvedic resin traditionally used for cholesterol and thyroid support. Indian studies showed dramatic cholesterol reductions, but Western replication trials found no benefit and one showed cholesterol actually increased. The discrepancy may be due to dietary differences between populations. May stimulate thyroid function — use caution with thyroid disorders. Can cause skin rash and digestive upset.

Dose: 500–1,000 mg/day guggulsterones extract; Indian results not replicated in Western trials