Green-lipped mussel (Perna canaliculus)

Tier 2 — promising · Joint · Anti-inflammatory · Omega-3

A New Zealand shellfish (Perna canaliculus) providing a unique lipid fraction including eicosatetraenoic acid (ETA), omega-3s, and furan fatty acids with anti-inflammatory activity distinct from standard fish oil. Meta-analyses show clinically meaningful reductions in osteoarthritis pain and stiffness, with effect sizes comparable to NSAIDs but better tolerance. Stabilised lipid extract (Lyprinol/Pernaton) has the strongest evidence; freeze-dried powders are less reliable. Avoid with shellfish allergy.

Dose: 200–400 mg standardised lipid extract or 1000–3000 mg freeze-dried powder daily