EGCG concentrate (decaffeinated green-tea catechin)

Tier 2 — promising · Antioxidant · Metabolic · Hepatotoxicity risk at high dose

Epigallocatechin-3-gallate is the principal catechin in green tea. Standardised decaffeinated EGCG extracts have moderate evidence for modest weight and lipid endpoints, and a smaller body of evidence for cancer adjunct use. Crucially, high-dose concentrated EGCG (>800 mg/day on empty stomach) has been linked to hepatotoxicity case reports — EFSA flagged this in 2018. Stay at or below the safety guidance dose, take with food, and discontinue if any liver-related symptoms develop.

Dose: 200–400 mg/day with food; do not exceed 800 mg/day per EFSA guidance