DIM (Diindolylmethane)

Tier 3 — weak evidence · Estrogen metabolism · Hormonal balance

A compound formed when digesting cruciferous vegetables. Small trials suggest it shifts estrogen toward less proliferative metabolites. NCCIH states evidence is insufficient for cancer prevention. Can meaningfully alter hormone levels — get a baseline hormone panel before use. Avoid if on HRT, oral contraceptives, or hormone-sensitive cancer treatment.

Dose: 100–200 mg/day with food; medical guidance needed if on HRT or oral contraceptives