DHEA topical cream

Tier 3 — weak evidence · Skin aging · Vaginal atrophy

Intravaginal DHEA (prasterone) is FDA-approved for postmenopausal vaginal dryness based on a large RCT. Topical skin application for anti-aging has weaker evidence. Systemic absorption from both routes can affect hormone levels. Should be used under medical supervision, particularly in hormone-sensitive conditions.

Dose: Vaginal: 6.5 mg/day intravaginal (prescription); topical skin: 1–2% cream; consult physician