Delta-tocotrienol

Tier 2 — promising · Cardiovascular · Anti-inflammatory · Cancer adjunct

A tocotrienol isomer (vitamin E family) derived from annatto or palm oil with distinct biological activity from tocopherols. Delta- and gamma-tocotrienols inhibit HMG-CoA reductase post-transcriptionally, reducing cholesterol synthesis — RCTs in hyperlipidaemia show 10–15% LDL reductions. Also shows promise in reducing inflammatory markers in NAFLD and in preclinical cancer adjunct work. Tocopherol-free (annatto-derived) preparations are preferred; alpha-tocopherol interferes with tocotrienol uptake.

Dose: 125–300 mg delta/gamma tocotrienols (annatto-sourced) daily