CBD (Cannabidiol)

Tier 3 — weak evidence · Anxiety · Sleep · Pain

Only the prescription drug Epidiolex has proven CBD benefits, and only for specific seizure disorders. The FDA's position is that CBD still cannot be legally marketed as a dietary supplement. Retail wellness products are largely untested — anxiety and sleep claims rely on weak studies. A 2024 analysis found 70% of products were mislabelled, some with no CBD. Also inhibits liver enzymes processing many drugs. Research doses are 5–10x higher than typical retail gummies.

Dose: Only pharmaceutical-grade Epidiolex is evidence-based (epilepsy only); retail wellness products lack clinical support