Capsinoids (CH-19 sweet pepper)

Tier 2 — promising · Weight management · Thermogenesis · Metabolic

Non-pungent analogues of capsaicin found in CH-19 sweet pepper. Unlike capsaicin, capsinoids do not activate oral TRPV1 receptors (no burning sensation), but stimulate intestinal TRPV1, activating sympathetically-driven fat oxidation and thermogenesis. Meta-analyses show consistent energy expenditure increases of 50–100 kcal/day and enhanced fat oxidation, particularly from visceral fat. No cardiovascular stimulation or GI irritation. Currently the safest thermogenic supplement option available.

Dose: 6–10 mg/day with meals