Black seed oil (Nigella sativa)

Tier 3 — weak evidence · Metabolic · Glucose · Lipids · BP

Multiple 2024–2025 reviews confirm it modestly lowers blood sugar, LDL cholesterol, triglycerides, and blood pressure. Active compound thymoquinone has anti-inflammatory properties. Most supporting trials are small and short-term — treat effect sizes cautiously. Caution: enhances blood pressure and diabetes medications. Use cold-pressed oil only — do not heat. Safety beyond 3 months is limited.

Dose: 1–3 g/day cold-pressed oil or 500 mg standardised extract; do not heat; monitor BP if on antihypertensives