Berberine

Tier 2 — promising · Metabolic · Glucose · Lipids

Lowers blood sugar, LDL cholesterol, triglycerides, and waist size — comparable to metformin in some head-to-head trials. A 2025 review confirms significant improvements across all metabolic markers. Warning: severe interactions with statins, metformin, diabetes drugs, and blood pressure meds (hypoglycemia, statin toxicity risk). Always consult your doctor before use.

Dose: 500 mg × 2–3 daily with meals + piperine; medical supervision required if on any prescription medication