Benfotiamine

Tier 2 — promising · Neuropathy · AGEs · Glucose metabolism

A fat-soluble form of vitamin B1 that absorbs about 5 times better than regular thiamine. A 2024 review of 7 trials found it significantly reduces diabetic nerve pain and sugar-related protein damage that contributes to complications. Very safe at recommended doses with no serious side effects. Especially useful for people with diabetes or prediabetes.

Dose: 300–600 mg/day in divided doses with meals