Avocado soybean unsaponifiables (ASU)

Tier 3 — weak evidence · Joint · OA

Extracted from avocado and soybean oils and studied for knee and hip OA. Several European RCTs found ASU reduced pain and improved function after 3–6 months. A large French trial showed reduced need for anti-inflammatory drugs. Effects are slow to appear (2–3 months). Widely prescribed in France but considered a supplement elsewhere.

Dose: 300 mg/day ASU; effects take 2–3 months to appear; best studied for knee and hip OA