Aged garlic extract (Kyolic)

Tier 2 — promising · Cardiovascular · Blood pressure · Immune

Regular garlic causes digestive upset and odour, but the aged extract form (Kyolic) is odourless and better tolerated. A meta-analysis by Ried (Exp Ther Med 2020) pooling 12 trials found aged garlic extract reduced systolic blood pressure by roughly 8 mmHg in hypertensive adults, with smaller effects in normotensive subjects. Coronary calcium trials (Budoff 2016) also suggest modestly reduced arterial plaque progression. The aging process converts harsh sulfur compounds into the gentler, more bioactive S-allyl cysteine.

Dose: 600–1,200 mg/day aged garlic extract (standardised to S-allyl cysteine)